Nurturing Life Sciences
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#Unit 3. Fundamental Processes
The Nova and Fox families of RNA-binding proteins can promote or suppress splice site selection in a context-dependent fashion.
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Trans-splicing is rare in multicellular eukaryotes, it occurs as the primary mechanism to process precursor RNA into mature, translatable mRNAs in some organisms, such as trypanosomes and nematodes.
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The SL RNA provides an exon that is connected to the first exon of an mRNA by trans-splicing. The reaction involves the same interactions as nuclear cis splicing but generates a Y-shaped RNA instead of a lariat.
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In C. elegans, about 70% of genes are processed by the trans-splicing mechanism
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A very different form of RNA editing is found in the RNA transcripts that encode proteins in the mitochondria of trypanosomes.
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