The cytosolic domain of RTKs contains an intrinsic protein tyrosine kinase domain.

TLS Online TPP Program

#Id: 1372

#Unit 4. Cell Communication and Cell Signaling

STAT homodimer has two phosphotyrosine-SH2 domain interactions

TLS Online TPP Program

#Id: 1373

#Unit 4. Cell Communication and Cell Signaling

 Phosphorylated STAT dissociates spontaneously from the receptor, dimerize & move into the nucleus.

 

TLS Online TPP Program

#Id: 1374

#Unit 4. Cell Communication and Cell Signaling

Erythropoietin,

• secreted by kidney cells

• promotes proliferation and differentiation of erythroid progenitor cells in the bone marrow to increase the number of mature red cells in the blood

TLS Online TPP Program

#Id: 1375

#Unit 4. Cell Communication and Cell Signaling

STAT5 becomes activated in erythroid progenitor cells,  induces expression of the protein Bcl-xL.

TLS Online TPP Program

#Id: 1376

#Unit 4. Cell Communication and Cell Signaling

Two mechanisms for terminating cytokine signal transduction

1.  Short-term regulation

2.  Long-term regulation

TLS Online TPP Program

#Id: 1377

#Unit 4. Cell Communication and Cell Signaling

Short-term regulation: 

JAK2 deactivation by SHP1 phosphatase