In resting state,  the activation loop is not phosphorylated and assumes a conformation that blocks kinase activity.

In insulin receptor, it prevents binding of ATP. 

In FGF receptor, it prevents binding of substrate.

TLS Online TPP Program

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#Unit 2. Cellular Organization

Plakins 

Proteins that linked intermediate filament network to the rest of the cytoskeleton. 

Eg: Plectin

TLS Online TPP Program

#Id: 368

#Unit 2. Cellular Organization

Supercoiling is related to two properties of genome

1. Packaging 

2. Linking number

TLS Online TPP Program

#Id: 369

#Unit 2. Cellular Organization

DNA Packaging or genome packaging is expressed in terms of Packaging Ratio=Original size/packed size  

TLS Online TPP Program

#Id: 370

#Unit 2. Cellular Organization

Linking number is topological property which is expressed as  Total No. of Base Pair/Base pair per turn.

TLS Online TPP Program

#Id: 371

#Unit 2. Cellular Organization

How to calculate linking number?

TLS Online TPP Program

#Id: 372

#Unit 2. Cellular Organization

If Lk <Lk0 and DLk is <0 means negative, then the DNA is said to be “negatively supercoiled.”