For most, but not all, RTKs, the weakly active kinase in each subunit is phosphorylate a key tyrosine in the activation loop of the other subunit (trans-phosphorylation)

TLS Online TPP Program

#Id: 9050

#Unit 4. Cell Communication and Cell Signaling

Member of family A of GPCRs -β-adrenergic receptors

Member of family B of GPCRs -glucagon receptor 

Member of family C of GPCRs -glutamate receptor

TLS Online TPP Program

#Id: 9051

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9052

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9053

#Unit 4. Cell Communication and Cell Signaling

Binding of cAMP by an R subunit of PKA occurs in a cooperative fashion; i.e., binding of the first cAMP molecule to CNB-B lowers the Kd for binding of the second cAMP to CNB-A.

TLS Online TPP Program

#Id: 9054

#Unit 4. Cell Communication and Cell Signaling

The activated β2-adrenergic receptor induces GDP-->GTP exchange on a stimulatory G protein (Gs).

TLS Online TPP Program

#Id: 9055

#Unit 4. Cell Communication and Cell Signaling