For most, but not all, RTKs, the weakly active kinase in each subunit is phosphorylate a key tyrosine in the activation loop of the other subunit (trans-phosphorylation)

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#Id: 879

#Unit 13. Methods in Biology

Short tandem repeats (STRs) are short repeated sequences of DNA (1–10 bp) that account for approximately  3% of the human genome.

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#Id: 880

#Unit 13. Methods in Biology

AAAAAAAAAAAAAAA (a 1-base repeat) and CACACACACACACACACACACA (a 2-basen repeating), CAGCAGCAGCAGCAGCAG (a 3 base repeating) are most common.

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#Id: 881

#Unit 13. Methods in Biology

Most STRs are found in the noncoding regions, while only about 8% locate in the coding regions.

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#Id: 882

#Unit 13. Methods in Biology

The genetic diseases caused by trinucleotide repeat SSRs within genes. Huntington disease (HD) is one of the approximately 20 such trinucleotide repeat diseases in humans. HD is transmitted as an autosomal dominant mutation.

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#Id: 883

#Unit 13. Methods in Biology

In humans, chromosome 19 has the highest density of STRs. Disease associated with SSR are called as Repeat expansion diseases.

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#Id: 884

#Unit 13. Methods in Biology

Most common cause of Repeat expansion is SLIPPAGE during replications.