In the basal state, 

GAPs inhibit RalA and Rab10 function by enhancing their rates of GTP hydrolysis

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#Unit 2. Cellular Organization

Interphase chromosomes occupy chromosome territories in the nucleus and are not entangled with each other

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#Unit 2. Cellular Organization

Heterochromatic regions, silenced genes, and gene-sparse regions of chromosomes are typically localized to the nuclear periphery.

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#Unit 2. Cellular Organization

Active genes/euchromatin are often found at the borders of chromosome territories, and active genes from several chromosomes may cluster in inter-chromosomal territories that are enriched in transcription machinery.

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#Unit 2. Cellular Organization

MARs are AT rich heterochromatic regions which contains cis-acting sites that regulate transcription, 5’ introns, and a recognition site for topoisomerase II is usually present in the MAR.

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#Unit 2. Cellular Organization

Presence of topoisomerase II binding sites shows high degree of negative supercoiling is usually present in the MAR.

TLS Online TPP Program

#Id: 488

#Unit 2. Cellular Organization

(MARs) also called scaffold attachment regions (SARs), or S/MARs in case of metaphase chromosome as the same sequences appear to attach to the protein substructure in both metaphase and interphase cells.