Nod-like receptors

The NLRs are a large family of cytosolic proteins activated by intracellular PAMPs

TLS Online TPP Program

#Id: 2324

#Unit 3. Fundamental Processes

Group II mitochondrial introns are excised by the same mechanism as nuclear pre-mRNAs via a lariat that is held together by a 2’–5’ bond.

TLS Online TPP Program

#Id: 2325

#Unit 3. Fundamental Processes

SR proteins are involved in exon definition in which they interact with U1 and U2AF forming commitment E complex.

 

TLS Online TPP Program

#Id: 2326

#Unit 3. Fundamental Processes

U11 base pairs with the 5’ splice sites; U12 base pairs with the branch point sequence near the 3’ splice site; and U4atac and U6atac provide analogous functions during the spliceosome assembly and activation of the spliceosome. 

U5 is same component in all splicing complexes

TLS Online TPP Program

#Id: 2327

#Unit 3. Fundamental Processes

Each snRNP contains a single snRNA (100-300 nt) and several (20) proteins. The U4 and U6 snRNPs are usually found together as a di-snRNP (U4/U6) particle.

TLS Online TPP Program

#Id: 2328

#Unit 3. Fundamental Processes

U1 snRNA consist of four hairpins, one intron pairing strands and one sm binding domains.

TLS Online TPP Program

#Id: 2329

#Unit 3. Fundamental Processes

Once DNA has been melted, the trajectory of the individual strands within the enzyme is no longer constrained by the rigidity of the double helix, allowing DNA to make its 90° turn at the active site.