In the absence of Wnt,

TCF is associated with transcriptional repressor proteins Groucho (Gro) that inhibit gene transcription in nucleus

TLS Online TPP Program

#Id: 8633

#Unit 2. Cellular Organization

Mutating or deleting the destruction box in mitotic cyclins prevented their ubiquitination and blocked cells from exiting mitosis.

TLS Online TPP Program

#Id: 8634

#Unit 2. Cellular Organization

At the metaphase to anaphase transition, APC/C bound to Cdc20 targets cyclins A /B and securin for degradation.

TLS Online TPP Program

#Id: 8635

#Unit 2. Cellular Organization

During late anaphase, telophase and G1, APC/C bound to Cdh1 targets B type cyclins and geminin for degradation.

TLS Online TPP Program

#Id: 8636

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8637

#Unit 2. Cellular Organization

The G1 cyclin-CDK complex (Cln3-CDK in yeast) stimulates the formation of G1/S phase cyclin-CDKs, which initiate bud formation, centrosome duplication, and DNA replication.

TLS Online TPP Program

#Id: 8638

#Unit 2. Cellular Organization

Once sufficient Cln3 is synthesized from its mRNA, Cln3-CDK complexes phosphorylate and inactivate the transcriptional repressor Whi5.