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TLS Online TPP Program

#Id: 10295

Allelic exclusion - Once allele’s functional protein is generated, rearrangement at the other allele is shut down

#Section 2: General Biology #T cells #Part B Pointers
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TLS Online TPP Program

#Id: 8156

#Section 3: Genetics, Cellular and Molecular Biology

Two different kinds of sorting signals:
Membrane cargo proteins carry cytoplasmic sorting signals
Soluble cargo proteins carry luminal sorting signals
TLS Online TPP Program

#Id: 8154

#Section 3: Genetics, Cellular and Molecular Biology

Sar1 GTPase drives the pinching off of COPII vesicles
ARF GTPase drives the pinching off of COPIvesicles
Dynamin GTPase drives the pinching off of clathrin-coated vesicles
TLS Online TPP Program

#Id: 8153

#Section 3: Genetics, Cellular and Molecular Biology

A second function of small GTPases in vesicle formation is in the pinching off of a completed vesicle from the parent membrane
TLS Online TPP Program

#Id: 8152

#Section 3: Genetics, Cellular and Molecular Biology

After the vesicle coat is complete, the Sec23 coat subunit promotes GTP hydrolysis causes disassembly of the coat.
TLS Online TPP Program

#Id: 8151

#Section 3: Genetics, Cellular and Molecular Biology

Sec12
acts as a GEF factor for Sar1
TLS Online TPP Program

#Id: 8150

#Section 3: Genetics, Cellular and Molecular Biology

Sar1 is the only GTPase switch protein activated at the ER membrane