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TLS Online TPP Program

#Id: 10352

B-cell activation

#Section 2: General Biology #B-cell #Part B Pointers
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TLS Online TPP Program

#Id: 8216

#Section 3: Genetics, Cellular and Molecular Biology

In nonselective autophagy, a bulk portion of cytoplasm is sequestered in autophagosomes
TLS Online TPP Program

#Id: 8215

#Section 3: Genetics, Cellular and Molecular Biology

Autophagy can be either
• Nonselective autophagy
• Selective autophagy
TLS Online TPP Program

#Id: 8213

#Section 3: Genetics, Cellular and Molecular Biology

Autophagy occurs in the following sequence of steps:

Induction by activation of mTOR complex 1

• Nucleation of autophagosome formation by ATG9

• Closure of the membrane cup to form autophagosome

• Fusion of the autophagosome with lysosomes, catalyzed by SNAREs.

• Digestion of the inner membrane and the lumenal contents of the autophagosome
TLS Online TPP Program

#Id: 8212

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8211

#Section 3: Genetics, Cellular and Molecular Biology

Autophagosome, or autophagic vesicle
formation of a flattened double-membrane cup-shaped structure that envelops a region of the cytosol or an entire organelle.
TLS Online TPP Program

#Id: 8210

#Section 3: Genetics, Cellular and Molecular Biology

Autophagy (“eating oneself”)
When cells are placed under stressful conditions, they have the capacity to recycle macromolecules for use as nutrients in a process of lysosomal degradation.