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Class II MHC transcriptional activator called CIITA and another transcription factor called RFX, have both been shown to activate the promoter of class II MHC genes.
Defects in these transcription factors cause one form of bare lymphocyte syndrome.

#Section 2: General Biology #Major histocompatibility complex #Part B Pointers
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TLS Online TPP Program

#Id: 8625

#Section 3: Genetics, Cellular and Molecular Biology

Human SCF complexes contain: 
Three core components - Cul1 subunit, RBX1, Skp1 
and a substrate-targeting F-box protein

TLS Online TPP Program

#Id: 8626

#Section 3: Genetics, Cellular and Molecular Biology

RBX1 is a RING finger–containing protein that binds the E2 ubiquitin-conjugating enzyme.

TLS Online TPP Program

#Id: 8627

#Section 3: Genetics, Cellular and Molecular Biology

phosphoserine/threonine-binding F-box protein is Skp2, which uses a series of leucine-rich repeats to bind to target proteins only when they are phosphorylated.

TLS Online TPP Program

#Id: 8628

#Section 3: Genetics, Cellular and Molecular Biology

APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

#Id: 8629

#Section 3: Genetics, Cellular and Molecular Biology

APC/C works with substrate-targeting factors called Cdc20 and Cdh1

TLS Online TPP Program

#Id: 8630

#Section 3: Genetics, Cellular and Molecular Biology

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