The Hardy-Weinberg law, when the assumptions are met, reproduction alone does not alter allelic or genotypic  frequencies.

Hardy-Weinberg law apply to a single locus (di-allelic/ multiple allele).

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Nonsynonymous mutations, on the other hand, alter the amino acid sequence of the protein and in many cases are detrimental to the fitness of the organism, so most of these mutations are eliminated by natural selection.

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M6P residues are generated in the cis-Golgi by two Golgi-resident enzymes. 

1. N-acetylglucosamine (GlcNAc) phosphotransferase
2. Phosphodiesterase

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After assembly of the matrix protein-Pex5-Pex14 complex, the matrix protein dissociates from Pex5 and is released into the peroxisomal matrix.

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Nucleotide changes, particularly those at the third position of the codon, that do not alter the amino acid sequence are called synonymous substitutions.

Nucleotide changes in a gene that alter the amino acid sequence of a protein are referred to as non-synonymous substitutions.