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TLS Online TPP Program

#Id: 7932

Signal sequence

ER targeting sequence, located at the N-terminus of the protein

#Section 3: Genetics, Cellular and Molecular Biology #Endoplasmic Reticulum #Part B Pointers
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TLS Online TPP Program

#Id: 8648

#Section 3: Genetics, Cellular and Molecular Biology

During exit from mitosis and G1, 
Cdh1 is de-phosphorylated and APC/Ccdh1 is active.
TLS Online TPP Program

#Id: 8649

#Section 3: Genetics, Cellular and Molecular Biology

During S phase and mitosis, 
Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.
TLS Online TPP Program

#Id: 8650

#Section 3: Genetics, Cellular and Molecular Biology

G1/S phase CDKs phosphorylate Cdh1 at the 
G1-S phase transition
TLS Online TPP Program

#Id: 8651

#Section 3: Genetics, Cellular and Molecular Biology

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1
TLS Online TPP Program

#Id: 8652

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8653

#Section 3: Genetics, Cellular and Molecular Biology

Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.