Signal sequences

contain one or more positively charged amino acids adjacent to a continuous stretch of 6–12 hydrophobic residues (known as the hydrophobic core)

TLS Online TPP Program

#Id: 8634

#Section 3: Genetics, Cellular and Molecular Biology

At the metaphase to anaphase transition, APC/C bound to Cdc20 targets cyclins A /B and securin for degradation.

TLS Online TPP Program

#Id: 8635

#Section 3: Genetics, Cellular and Molecular Biology

During late anaphase, telophase and G1, APC/C bound to Cdh1 targets B type cyclins and geminin for degradation.

TLS Online TPP Program

#Id: 8636

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8637

#Section 3: Genetics, Cellular and Molecular Biology

The G1 cyclin-CDK complex (Cln3-CDK in yeast) stimulates the formation of G1/S phase cyclin-CDKs, which initiate bud formation, centrosome duplication, and DNA replication.

TLS Online TPP Program

#Id: 8638

#Section 3: Genetics, Cellular and Molecular Biology

Once sufficient Cln3 is synthesized from its mRNA, Cln3-CDK complexes phosphorylate and inactivate the transcriptional repressor Whi5.

TLS Online TPP Program

#Id: 8639

#Section 3: Genetics, Cellular and Molecular Biology

Phosphorylation of Whi5 promotes its export out of the nucleus, allowing the transcription factor complex SBF to induce transcription of the G1/S phase cyclin genes CLN1 and CLN2.