The SRP and the nascent polypeptide chain–ribosome complex bind to the SRP receptor in the ER membrane. This interaction is strengthened by the binding of GTP to both the SRP and its receptor.

TLS Online TPP Program

#Id: 8337

#Section 3: Genetics, Cellular and Molecular Biology

Profilin – G-actin nucleotide exchange (ADP to ATP) 

Cofilin – F-actin disassembly

Thymosin B-4 – G-actin monomer sequestering

TLS Online TPP Program

#Id: 8336

#Section 3: Genetics, Cellular and Molecular Biology

Actin filament treadmilling is accelerated by:

Profilin and Cofilin

TLS Online TPP Program

#Id: 8335

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8334

#Section 3: Genetics, Cellular and Molecular Biology

Phalloidin 

isolated from Amanita phalloides, binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing depolymerization.

TLS Online TPP Program

#Id: 8333

#Section 3: Genetics, Cellular and Molecular Biology

Jasplakinolide,

a sponge toxin, enhances nucleation by binding and stabilizing actin dimers and lowering the Cc.

TLS Online TPP Program

#Id: 8332

#Section 3: Genetics, Cellular and Molecular Biology

Latrunculin, 

a toxin secreted by sponges, binds and sequesters G-actin