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Hac1 activates transcription of genes encoding several protein-folding catalysts.

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Binding of the extracellular TCR domain to a MHC-peptide complex triggers activation of ZAP70 protein tyrosine kinases attached to the cytosolic domains of the two adjacent ΞΆ chains. 

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The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

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Population genetics, applies the principles of transmission genetics to large groups of individuals. 

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