Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

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Average fitness

In a species, only 1 of every 1000 seeds survives to reproductive age, and that those that survive produce an average of 3000 seeds. 

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Selection coefficient

A related variable is the selection coefficient (s), which is the relative intensity of selection against a  genotype

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The selection gradient measures the strength of directional selection acting on a quantitative trait.

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Proportional contribution of genotypes to population