The two ends of microfilament polymerize at different rates:

fast-growing end - plus end

slow-growing end - minus end

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Effector proteins of Rab6 is Kinesin

Effector proteins of Rab27 is Type V Myosin

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In mammalian cells, Rab5 protein (early endosomes) and its effector protein known as EEA1 (early endosome antigen 1)

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In yeast Rab protein is the Sec4 and its effectors are exocyst and Type V Myosin.

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Rab·GTP is enabled to bind to a variety of different proteins, known as Rab effectors.

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Rab GTPases 

associate with transport vesicles and act as key regulators of vesicle trafficking to and fusion with the appropriate target membrane.

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Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.