Cytochalasin D, 

a fungal alkaloid, depolymerizes actin filaments by binding to the (+) end of F-actin.

TLS Online TPP Program

#Id: 8851

#Section 3: Genetics, Cellular and Molecular Biology

Geminin is expressed in late G1; it binds to and inhibits Cdt1 preventing reloading of the MCM helicase.

TLS Online TPP Program

#Id: 8852

#Section 3: Genetics, Cellular and Molecular Biology

Geminin contains a destruction box at its N-terminus that is recognized by APC/Ccdh1, causing it to be ubiquitinylated in late anaphase and degraded by proteasomes.

TLS Online TPP Program

#Id: 8853

#Section 3: Genetics, Cellular and Molecular Biology

Cohesins 

The protein ring complexes that establish linkages between sister chromatids

TLS Online TPP Program

#Id: 8854

#Section 3: Genetics, Cellular and Molecular Biology

Cohesins establish linkages between the replicated DNA molecules, which are essential for their accurate segregation later in the cell cycle. This linking mechanism is coupled to DNA replication.

TLS Online TPP Program

#Id: 8855

#Section 3: Genetics, Cellular and Molecular Biology

Cohesins are composed of four subunits: 

Smc1, Smc3, Scc1, and Scc3

TLS Online TPP Program

#Id: 8856

#Section 3: Genetics, Cellular and Molecular Biology

Smc1 and Smc3 are members of the structural

maintenance of chromosomes (SMC) protein family, characterized by globular domains at the N- & C-termini connected by a long α helix, bind and hydrolyze ATP.