Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks

TLS Online TPP Program

#Id: 8146

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8145

#Section 3: Genetics, Cellular and Molecular Biology

Vesicle Type- Clathrin

Transport - trans-Golgi to endosome

Coat Proteins – Clathrin + AP1 complexes

                            Clathrin + GGA

Associated GTPase- ARF

TLS Online TPP Program

#Id: 8144

#Section 3: Genetics, Cellular and Molecular Biology

Vesicle Type- COPI

Transport - cis-Golgi to ER

Coat Proteins – Coatomers

Associated GTPase- ARF

TLS Online TPP Program

#Id: 8143

#Section 3: Genetics, Cellular and Molecular Biology

Vesicle Type- COPII

Transport - ER to cis-Golgi 

Coat Proteins - Sec23/Sec24 and Sec13/Sec31, Sec16

Associated GTPase- Sar1

TLS Online TPP Program

#Id: 8142

#Section 3: Genetics, Cellular and Molecular Biology

Retrograde transport

COPI vesicles = cis-Golgi to ER

TLS Online TPP Program

#Id: 8141

#Section 3: Genetics, Cellular and Molecular Biology

Anterograde transport through the golgi occurs by cisternal maturation