One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.

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#Section 3: Genetics, Cellular and Molecular Biology

Profilin can bind proteins with sequences rich in proline residues at the same time it is bound to actin.

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#Section 3: Genetics, Cellular and Molecular Biology

Profilin – G-actin nucleotide exchange (ADP to ATP) 

Cofilin – F-actin disassembly

Thymosin B-4 – G-actin monomer sequestering

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#Section 3: Genetics, Cellular and Molecular Biology

Actin filament treadmilling is accelerated by:

Profilin and Cofilin

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#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

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#Section 3: Genetics, Cellular and Molecular Biology

Phalloidin 

isolated from Amanita phalloides, binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing depolymerization.

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#Section 3: Genetics, Cellular and Molecular Biology

Jasplakinolide,

a sponge toxin, enhances nucleation by binding and stabilizing actin dimers and lowering the Cc.