Troponin, a complex of three polypeptides, 

TN-T (tropomyosin-binding)

TN-I  (inhibitory)

TN-C (Ca2+-binding)

TLS Online TPP Program

#Id: 8403

#Section 3: Genetics, Cellular and Molecular Biology

AP activates a  voltage gated Ca2+ channel in the T-tubule membrane, it triggers the opening of a Ca2+ -release channel in the closely associated SR membrane

TLS Online TPP Program

#Id: 10371

#Section 2: General Biology

A given MHC molecule can bind numerous different peptides, and some peptides can bind to several different MHC molecules. Because of this MHC molecule is often referred to as “promiscuous”.

TLS Online TPP Program

#Id: 9184

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 10291

#Section 2: General Biology

The second phase of T-cell development

1.Positive selection: Selection for those cells whose T-cell receptors engage self-MHC.

2.Negative selection: Selection against those cells whose T-cell receptors bind too strongly to self-peptide/MHC combinations.

3.Lineage commitment: Commitment of thymocytes to effector cell lineages, including CD4 helper or CD8 cytotoxic populations

TLS Online TPP Program

#Id: 8225

#Section 3: Genetics, Cellular and Molecular Biology

Hurler’s disease- mutation in a structural gene that codes for an individual lysosomal hydrolase.