Catastrophe 

The change from growth to shrinkage

TLS Online TPP Program

#Id: 8887

#Section 3: Genetics, Cellular and Molecular Biology

The mitotic CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate during prophase. 

TLS Online TPP Program

#Id: 8888

#Section 3: Genetics, Cellular and Molecular Biology

A key function of mitotic CDKs, together with other protein kinases and ubiquitin-protein ligases, is to induce the formation of the mitotic spindle, also known as the mitotic apparatus.

TLS Online TPP Program

#Id: 8889

#Section 3: Genetics, Cellular and Molecular Biology

Centrosomes contain γ tubulin, which forms specific ringlike complexes (γ TuRCs) that, have the ability to nucleate microtubules and form a bipolar spindle

TLS Online TPP Program

#Id: 8890

#Section 3: Genetics, Cellular and Molecular Biology

Mitotic spindle attach to chromosomes via specialized protein structures known as kinetochores

TLS Online TPP Program

#Id: 8891

#Section 3: Genetics, Cellular and Molecular Biology

Kinetochores assemble on regions of chromosomal DNA marked by a centromere-specific H3 histone variant called CENP-A.

TLS Online TPP Program

#Id: 8892

#Section 3: Genetics, Cellular and Molecular Biology

Amphitelic attachment, 

sister kinetochores attach to microtubules emanating from opposite spindle poles, they are stably attached