Nonphosphorylated CDK bound to one of its cyclin partners has minimal but detectable protein kinase activity in vitro, although it may be essentially inactive in vivo.

TLS Online TPP Program

#Id: 8520

#Section 3: Genetics, Cellular and Molecular Biology

Post-translational modifications of tubulin:

Lysine acetylation

Detyrosylation

Polyglutamylation

Polyglycylation

TLS Online TPP Program

#Id: 8519

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8518

#Section 3: Genetics, Cellular and Molecular Biology

Defects in LIS1 

Miller-Dieker lissencephaly

means “smooth brain”

TLS Online TPP Program

#Id: 8517

#Section 3: Genetics, Cellular and Molecular Biology

Other proteins function with dynein & involved in regulating the activity of dynein during brain development:

LIS1 and NudE

TLS Online TPP Program

#Id: 8516

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8515

#Section 3: Genetics, Cellular and Molecular Biology

Kinesin-1 

is regulated by a 

head-to-tail interaction