Phosphorylation of T14 and Y15 in this G-loop

introduces negative charge that electrostatically interferes with the binding of ATP in the catalytic pocket.

TLS Online TPP Program

#Id: 8318

#Section 3: Genetics, Cellular and Molecular Biology

Nucleation phase 

Two G-actin molecules bind relatively weakly to each other, but addition of a third actin monomer to form a trimer makes the entire group more stable, acts as a nucleus for polymerization.

TLS Online TPP Program

#Id: 8338

#Section 3: Genetics, Cellular and Molecular Biology

Profilin can bind proteins with sequences rich in proline residues at the same time it is bound to actin.

TLS Online TPP Program

#Id: 8415

#Section 3: Genetics, Cellular and Molecular Biology

Dilated cardiomyopathy

Minor missense mutations in the cardiac actin gene

TLS Online TPP Program

#Id: 8864

#Section 3: Genetics, Cellular and Molecular Biology

Defects of cohesin’s gene expression regulation function are the cause of a group of diseases collectively called cohesinopathies.

TLS Online TPP Program

#Id: 8608

#Section 3: Genetics, Cellular and Molecular Biology

There are three D cyclins in mammals:

cyclins D1, D2, and D3