Cyclins are degraded through the action of two different E3-ligases:

1. SCF (Skp1, Cullin, and F-box proteins) 

2. APC/C or cyclosome

TLS Online TPP Program

#Id: 10335

#Section 2: General Biology

TLS Online TPP Program

#Id: 9292

#Section 2: General Biology

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#Id: 3776

#Section 2: General Biology

Elements are made of atoms. While the atoms may have different weights and organization, they are all built in the same way.

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#Id: 8404

#Section 3: Genetics, Cellular and Molecular Biology

The increase in Ca2+ concentration is transient because the Ca2+ is rapidly pumped back into the SR by an abundant, Ca2+ ATPase.

TLS Online TPP Program

#Id: 8629

#Section 3: Genetics, Cellular and Molecular Biology

APC/C works with substrate-targeting factors called Cdc20 and Cdh1