In budding yeast CKI p27 = Sic1 in metazoans

TLS Online TPP Program

#Id: 8865

#Section 3: Genetics, Cellular and Molecular Biology

The phosphorylation state of T14 and Y15 is controlled by a dual-specificity protein kinase known as Wee1 and a pair of dual-specificity phosphatases, Cdc25B and Cdc25C (Threonine 14 is not phosphorylated in S. pombe CDK1)

TLS Online TPP Program

#Id: 8654

#Section 3: Genetics, Cellular and Molecular Biology

Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase

TLS Online TPP Program

#Id: 8877

#Section 3: Genetics, Cellular and Molecular Biology

The pool of active Cdc25C is created, that activates the large pool of cytosolic cyclin B-CDK1, which activates more cytosolic Cdc25C as part of positive feedback loop 1

TLS Online TPP Program

#Id: 8411

#Section 3: Genetics, Cellular and Molecular Biology

In the absence of Ca2+, muscle is relaxed

TM blocks myosin’s interaction with F-actin

TLS Online TPP Program

#Id: 8337

#Section 3: Genetics, Cellular and Molecular Biology

Profilin – G-actin nucleotide exchange (ADP to ATP) 

Cofilin – F-actin disassembly

Thymosin B-4 – G-actin monomer sequestering