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This phosphorylation, together with phosphorylation of lamin B by protein kinase C, causes depolymerization of the lamin intermediate filaments.

#Section 3: Genetics, Cellular and Molecular Biology #Steps in cell cycle, regulation and control of cell cycle #Part B Pointers
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Nonsynonymous mutations, on the other hand, alter the amino acid sequence of the protein and in many cases are detrimental to the fitness of the organism, so most of these mutations are eliminated by natural selection.

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