Mixtures of exons duplicated from genes with different functions can generate new genes with new functions, a process that is called exon shuffling.

TLS Online TPP Program

#Id: 8625

#Section 3: Genetics, Cellular and Molecular Biology

Human SCF complexes contain: 

Three core components - Cul1 subunit, RBX1, Skp1 

and a substrate-targeting F-box protein

TLS Online TPP Program

#Id: 8626

#Section 3: Genetics, Cellular and Molecular Biology

RBX1 is a RING finger–containing protein that binds the E2 ubiquitin-conjugating enzyme.

TLS Online TPP Program

#Id: 8627

#Section 3: Genetics, Cellular and Molecular Biology

phosphoserine/threonine-binding F-box protein is Skp2, which uses a series of leucine-rich repeats to bind to target proteins only when they are phosphorylated.

TLS Online TPP Program

#Id: 8628

#Section 3: Genetics, Cellular and Molecular Biology

APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

#Id: 8629

#Section 3: Genetics, Cellular and Molecular Biology

APC/C works with substrate-targeting factors called Cdc20 and Cdh1

TLS Online TPP Program

#Id: 8630

#Section 3: Genetics, Cellular and Molecular Biology