If the duplicate is redundant and does not provide a fitness benefit, it will be lost by deletion or the accumulation of loss of-function mutations.

A second fate is that a duplicate can simply retain its original function.

TLS Online TPP Program

#Id: 8640

#Section 3: Genetics, Cellular and Molecular Biology

In vertebrates, Rb is the major guardian of the cell cycle, integrating information about DNA damage and cell growth

TLS Online TPP Program

#Id: 8093

#Section 2: General Biology

TLS Online TPP Program

#Id: 10384

#Section 2: General Biology

Class II MHC transcriptional activator called CIITA and another transcription factor called RFX, have both been shown to activate the promoter of class II MHC genes.

Defects in these transcription factors cause one form of bare lymphocyte syndrome.

TLS Online TPP Program

#Id: 8212

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8968

#Section 3: Genetics, Cellular and Molecular Biology