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The phosphorylated Ci is proteolytically cleaved by the ubiquitin-proteasome pathway, generating an N-terminal fragment Ci75, which functions as a transcriptional repressor of Hh target genes.

#XL - T Zoology #Hedgehog Signaling #Part B Pointers
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#XL - T Zoology

Change in environmental condition is not necessary for natural selection.

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Before Darwin
Christians interpreted- “special creation”

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Carolus Linnaeus- Classified “related” species into genera, “related” genera into orders, and so on.

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James Hutton and Charles Lyell- Uniformitarianism

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Chevalier de Lamarck- Inheritance of acquired characteristics

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Neo-Lamarckism- August Weismann cut off the tails of mice for many generations and showed that this mutilation had no effect on the tail length of their descendants

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