Several integrin α subunits contain, I-domain, which can mediate binding of integrins to various collagens in the ECM.

TLS Online TPP Program

#Id: 9042

#XL - T Zoology

Heterotrimeric G proteins directly bind to and are activated by G protein coupled receptors.

TLS Online TPP Program

#Id: 9043

#XL - T Zoology

Switching mechanism of monomeric G proteins 

“On” state, switch I and switch II, are bound to the terminal γ phosphate of GTP with the backbone amide groups of conserved T & G.

TLS Online TPP Program

#Id: 9044

#XL - T Zoology

TLS Online TPP Program

#Id: 9045

#XL - T Zoology

Switching mechanism of monomeric G proteins 

“Off” state, Removal of the γ phosphate by GTPase-catalyzed hydrolysis causes switch I and switch II to relax into a different conformation

TLS Online TPP Program

#Id: 9046

#XL - T Zoology

Monomeric G proteins, including Ras and various Ras-like proteins, do not directly bind to receptors but act as intermediate proteins in signal transduction pathways.

TLS Online TPP Program

#Id: 9047

#XL - T Zoology

Monomeric G proteins are evolutionarily ancient, as evidenced by their widespread functions examples include: 

eIF2

EF1α and EF2

Ran

Sar

Rab

Rho, Rac, and Cdc42