B-cell survival in the follicle is dependent on access to the TNF-family member cytokine B-cell activation factor (BAFF), otherwise known as B lymphocyte survival factor (BLyS), which is secreted by the FDCs.

TLS Online TPP Program

#Id: 9834

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Red light-induced Pfr formation initiates the degradation of PIF proteins through phosphorylation, followed by degradation via the proteasome complex

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#Id: 9835

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#Id: 9836

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CONSTITUTIVE PHOTOMORPHOGENESIS1 (COP1), another negative regulator of photomorphogenesis, is a component of the E3 ubiquitin ligase complex that targets photomorphogenesis-promoting proteins for degradation such as phyA, phyB.

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#Id: 9837

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COP1 is found in the nucleus in the dark and in the cytoplasm in the light. COP1 movement into the nucleus in the dark requires the COP9 signalosome (CSN) complex

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#Id: 9838

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In the dark, COP1, an E3 ligase, ubiquitinates HY5.

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#Id: 9839

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