Properties of thymus-dependent and thymus-independent antigens

TLS Online TPP Program

#Id: 10366

#XL - Q Biochemistry

Class I MHC, glycoproteins expressed on the surface of nearly all nucleated cells; the major function of the class I is presentation of endogenous peptide antigens to CD8+ T cells.

TLS Online TPP Program

#Id: 10367

#XL - Q Biochemistry

Daudi tumor cells, which are unable to synthesize β 2-microglobulin. 

TLS Online TPP Program

#Id: 10368

#XL - Q Biochemistry

Class II MHC glycoproteins expressed predominantly on pAPCs, where they primarily present exogenous antigenic peptides to CD4+ T cells.

TLS Online TPP Program

#Id: 10369

#XL - Q Biochemistry

Class III MHC genes encode several different proteins, some with immune functions, include the complement components C4, C2, and factor B, TNF-α and Lymphotoxin-α [TNF- α]. 

TLS Online TPP Program

#Id: 10370

#XL - Q Biochemistry

HLA-G

These are present on fetal cells at the maternal-fetal interface and are credited with inhibiting rejection by maternal CD8+ T cells by protecting the fetus from identification as foreign.

TLS Online TPP Program

#Id: 10371

#XL - Q Biochemistry

A given MHC molecule can bind numerous different peptides, and some peptides can bind to several different MHC molecules. Because of this MHC molecule is often referred to as “promiscuous”.