When cellular iron concentrations return to normal levels, IRP1 is converted to aconitase, and IRP2 undergoes proteolytic degradation, ending the low-iron response.

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Myosin I

single head domain

Function- Membrane association, endocytosis

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Three classes of myosins:

Myosin I

Myosin II

Myosin V

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The first myosin discovered

Myosin II, was isolated from skeletal muscle.

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Myosins have 

Motor head domain

Lever-arm neck domain

Cargo-binding tail domain

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Myosin 

Actin-based motors powered by ATP hydrolysis.

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