The overall change in allelic frequency is a balance between the opposing forces of forward mutation and reverse  mutation:

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The activities of GPK and GP are inhibited by a phosphatase called phosphoprotein phosphatase.

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The promoter or enhancer segments of all genes regulated by PKA contain a cis-acting DNA sequence, the cAMP-response element (CRE), which

contains the highly conserved nucleotide sequence,

5'-TGACGTCA-3'.

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In nucleus PKA phosphorylate serine-133 on a transcription factor called CREbinding (CREB) protein

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Phosphorylated CREB binds to CRE-containing target genes and also binds to the co-activator termed CBP/P300, thereby stimulating gene transcription

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Inactive PKA is a tetramer consisting of- 

two regulatory (R) subunits

two catalytic (C) subunits