When the anomeric hydroxyl of a D-hexose is on the same side of the ring as C-6, the structure is β a by definition; when it is on the opposite side from C-6, the structure is α.

TLS Online TPP Program

#Id: 1353

#XL - T Zoology

GRB2 SH2 domain binds to a specific phosphotyrosine residue in the cytosolic domain of an activated RTK.

 

TLS Online TPP Program

#Id: 1354

#XL - T Zoology

The SH2 domain binds strongly to any peptide containing a critical four-residue core sequence:  phosphotyrosine–glutamic acid–glutamic acid–isoleucine

TLS Online TPP Program

#Id: 1355

#XL - T Zoology

MEK, a dual-specificity protein kinase

TLS Online TPP Program

#Id: 9032

#XL - T Zoology

TLS Online TPP Program

#Id: 9033

#XL - T Zoology

TLS Online TPP Program

#Id: 9034

#XL - T Zoology

Ligand binding depends on: 

Multiple weak, noncovalent forces

Molecular complementarity