The ER captures selected proteins from the cytosol as they are being synthesized. These are of two types:

Transmembrane proteins

Water-soluble proteins

TLS Online TPP Program

#Id: 9683

#XL - T Zoology

Loss of the PTEN protein contributes to the uncontrolled growth of cells.

TLS Online TPP Program

#Id: 9684

#XL - T Zoology

Insulin receptor leads to the activation of PKB

TLS Online TPP Program

#Id: 9685

#XL - T Zoology

Main action of the PKB signaling pathway

An increase in uptake of glucose from the blood within minutes.

TLS Online TPP Program

#Id: 9686

#XL - T Zoology

Fat and muscle cells express large amounts of the insulin-responsive glucose transporter GLUT4

TLS Online TPP Program

#Id: 9687

#XL - T Zoology

In resting cells, the majority of the GLUT4 protein is

localized to specialized GLUT4 storage vesicles (GSVs)

TLS Online TPP Program

#Id: 9688

#XL - T Zoology

GSVs tethered to the Golgi matrix, by a protein termed TUG (Tether containing a UBX domain for GLUT4).