The SRP and the nascent polypeptide chain–ribosome complex bind to the SRP receptor in the ER membrane. This interaction is strengthened by the binding of GTP to both the SRP and its receptor.

TLS Online TPP Program

#Id: 10297

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 10298

#XL - Q Biochemistry

T-cell education

TLS Online TPP Program

#Id: 10299

#XL - Q Biochemistry

Lineage commitment

TLS Online TPP Program

#Id: 10300

#XL - Q Biochemistry

T-Cell Activation and Differentiation

TLS Online TPP Program

#Id: 10301

#XL - Q Biochemistry

Three signals are required for activation of a naïve T cell

TLS Online TPP Program

#Id: 10302

#XL - Q Biochemistry

Positive Costimulatory Receptors: ICOS

ICOS binds to another member of the growing B7 family, ICOS-ligand (ICOS-L), which is also expressed on a subset of activated APCs.

ICOS plays a key role in maintaining the activity of already differentiated effector and memory T cells.