Major component of ecological niche

1. Space Habitat

2. Eating habit

3. Environmental variant

TLS Online TPP Program

#Id: 9674

#XL - T Zoology

Maximal activation of PKB depends on recruitment to the cytosolic surface of the plasma membrane of two other kinases -PDK1 and PDK2.

TLS Online TPP Program

#Id: 9675

#XL - T Zoology

PDK1 can phosphorylate PKB on a critical threonine residue in its activation loop

TLS Online TPP Program

#Id: 9676

#XL - T Zoology

Phosphorylation by the mTORC2 kinase complex, of a second serine on

PKB that is not in the activation loop is necessary for maximal PKB activity

TLS Online TPP Program

#Id: 9677

#XL - T Zoology

Activated PKB directly phosphorylates and inactivates a protein Bad

TLS Online TPP Program

#Id: 9678

#XL - T Zoology

Activated PKB also promotes survival of many cultured cells by phosphorylating the Forkhead transcription factor FOXO3a on multiple serine and threonine residues.

TLS Online TPP Program

#Id: 9679

#XL - T Zoology

The cytosolic phosphoserine binding protein 14-3-3 then binds to phosphorylated FOXO3a and sequesters it in the cytosol.