His ionisation series

1------pK1-----pKr--------pKr------14

TLS Online TPP Program

#Id: 9716

#XL - T Zoology

Ste7, phosphorylates and activates Fus3,  a serine/threonine kinase

TLS Online TPP Program

#Id: 9717

#XL - T Zoology

Fus3 equivalent to MAP kinase

TLS Online TPP Program

#Id: 9718

#XL - T Zoology

Fus3 translocates into the nucleus & phosphorylates two proteins, Dig1 and Dig2.

TLS Online TPP Program

#Id: 9719

#XL - T Zoology

Phosphorylated Dig1 and Dig2, relieves the inhibition of the Ste12 transcription factor.

TLS Online TPP Program

#Id: 9720

#XL - T Zoology

Activated Ste12, induces expression of proteins

involved in mating-specific cellular responses.

TLS Online TPP Program

#Id: 9956

#XL - T Zoology

Human genome encodes 19 different Wnt proteins, and essential for critical developmental events, including:

Brain development

Limb patterning

Organogenesis

Formation of osteoblasts