A Pex 2, Pex 10, and Pex 12 complex embedded in the peroxisomal membrane transfers Ubiquitin to two embedded Pex 5 receptors.

TLS Online TPP Program

#Id: 8343

#XL - Q Biochemistry

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8342

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8341

#XL - Q Biochemistry

Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks

TLS Online TPP Program

#Id: 8340

#XL - Q Biochemistry

Gelsolin, is regulated by Ca+2 ion concentration and sever actin filaments.

TLS Online TPP Program

#Id: 8339

#XL - Q Biochemistry

Filament capping proteins:

CapZ blocks (+)end Tropomodulin blocks (-)end

TLS Online TPP Program

#Id: 8338

#XL - Q Biochemistry

Profilin can bind proteins with sequences rich in proline residues at the same time it is bound to actin.