3 isoforms of actin-

α - expressed only in muscle cells

β and γ - found together in almost all non-muscle cells

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MCSs also serve as interfaces for the transfer of ions (Ca+2 ) and small molecules (glycerophospholipids) between the ER and mitochondria.

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Mutation

Mutation has changed the allelic frequency.

it increases genetic variation within populations and between population.

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In the absence of Hh,

Ptc inhibits Smoothened and then degraded in proteasomes

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