formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 10389

#XL - Q Biochemistry

Class II, but not class I, presentation is inhibited by treatment of the cells with an agent that blocks endocytic processing within the cell (chloroquine).

TLS Online TPP Program

#Id: 10286

#XL - Q Biochemistry

T cells initiate the adaptive immune response by interacting MHC on antigen-presenting cells that have been exposed to pathogens. 

TLS Online TPP Program

#Id: 10287

#XL - Q Biochemistry

T-Cell - Cells leaving the thymus are functional, mature T cells expressing unique and specific T-cell receptors (TCRs) that are both tolerant to self and restricted to self-MHC.

TLS Online TPP Program

#Id: 10288

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 10289

#XL - Q Biochemistry

T-cell lineage

TLS Online TPP Program

#Id: 10290

#XL - Q Biochemistry

T-Cell Development

1.Commitment

2.antigen receptor gene rearrangements

3.The selection and expansion of cells (β-selection