Kinesin-1 

is regulated by a 

head-to-tail interaction

TLS Online TPP Program

#Id: 9648

#XL - T Zoology

MEK is a dual-specificity protein kinase

phosphorylates its target proteins on both tyrosine and serine/threonine

TLS Online TPP Program

#Id: 9649

#XL - T Zoology

In humans, there are three RAS, three Raf, two MEK, and two MAP proteins.

TLS Online TPP Program

#Id: 9650

#XL - T Zoology

Mammalian MAP kinases include  Jun N-terminal kinases and p38 kinases, which are activated by signaling pathways in response to various types of stresses

TLS Online TPP Program

#Id: 9651

#XL - T Zoology

Phosphorylation by MEK at Y-185 and T-183 in activation loop of MAP kinase leads to a marked conformational change & promotes MAP kinase activation and dimerization.

TLS Online TPP Program

#Id: 9652

#XL - T Zoology

TLS Online TPP Program

#Id: 9653

#XL - T Zoology

Activated dimeric MAP kinase induces transcription of the c-fos gene by directly activating TCF, and indirectly activating SRF.