In the situation where Ki< K1, This form of mixed inhibition has been termed noncompetitive- uncompetitive inhibition

TLS Online TPP Program

#Id: 8645

#XL - T Zoology

Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.

TLS Online TPP Program

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#XL - T Zoology

One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

TLS Online TPP Program

#Id: 8647

#XL - T Zoology

TLS Online TPP Program

#Id: 8648

#XL - T Zoology

During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

TLS Online TPP Program

#Id: 8649

#XL - T Zoology

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

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#XL - T Zoology

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition