APC/CCdc²⁰ is inhibited by a checkpoint pathway that ensures that anaphase is not initiated until all chromosomes have achieved proper attachment to the mitotic apparatus.

TLS Online TPP Program

#Id: 8947

#XL - T Zoology

An inhibitor of Kin4, called Lte1, localizes to the bud but is absent from the parent cell; it inhibits any residual Kin4 that leaks into the bud.

TLS Online TPP Program

#Id: 8948

#XL - T Zoology

When spindle microtubule elongation at the end of anaphase has correctly positioned segregating daughter chromosomes in the bud, Tem1 is converted into its active GTP-bound state, activating the protein kinase signaling cascade.

TLS Online TPP Program

#Id: 8949

#XL - T Zoology

TLS Online TPP Program

#Id: 1313

#XL - T Zoology

Two large classes of GTPase switch proteins-

Heterotrimeric G proteins

Monomeric G proteins

TLS Online TPP Program

#Id: 1314

#XL - T Zoology

GTP-binding switch proteins contains two domain-

Switch I- Thr-35

Switch II- Gly-60 

TLS Online TPP Program

#Id: 1315

#XL - T Zoology

GTPase superfamily of proteins- eIF2, EF1α, EF2, Ran, Sar, Rab, Rho, Rac, Cdc42