In S. cerevisiae, during interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. 

TLS Online TPP Program

#Id: 8702

#XL - R Botany

TLS Online TPP Program

#Id: 8703

#XL - R Botany

TLS Online TPP Program

#Id: 8704

#XL - R Botany

TLS Online TPP Program

#Id: 8705

#XL - R Botany

The cytosolic isozyme has two distinct functions. It catalyzes the conversion of citrate to isocitrate, providing the substrate for a cytosolic isocitrate dehydrogenase that generates NADPH as reducing power for fatty acid synthesis and other anabolic processes in the cytosol. It also has a role in cellular iron homeostasis.

TLS Online TPP Program

#Id: 8706

#XL - R Botany

TLS Online TPP Program

#Id: 8707

#XL - R Botany

KDC shows Divergent evolution, in which the genes for an enzyme with one substrate specificity give rise, during evolution, to closely related enzymes with different substrate specificities but the same enzymatic mechanism.