Binding of cAMP by an R subunit of PKA occurs in a cooperative fashion; i.e., binding of the first cAMP molecule to CNB-B lowers the Kd for binding of the second cAMP to CNB-A.

TLS Online TPP Program

#Id: 8521

#XL - Q Biochemistry

Lysine acetylation & Detyrosylation are found only on α-tubulin and are absent from β-tubulin.

TLS Online TPP Program

#Id: 8520

#XL - Q Biochemistry

Post-translational modifications of tubulin:

Lysine acetylation

Detyrosylation

Polyglutamylation

Polyglycylation

TLS Online TPP Program

#Id: 8519

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8518

#XL - Q Biochemistry

Defects in LIS1 

Miller-Dieker lissencephaly

means “smooth brain”

TLS Online TPP Program

#Id: 8517

#XL - Q Biochemistry

Other proteins function with dynein & involved in regulating the activity of dynein during brain development:

LIS1 and NudE

TLS Online TPP Program

#Id: 8516

#XL - Q Biochemistry