In response to elevated cytosolic Ca²+ 

PKC is recruited to the plasma membrane, where it is activated by DAG

TLS Online TPP Program

#Id: 8221

#XL - Q Biochemistry

The M6P receptor protein binds to M6P at pH 6.5–6.7 in the TGN lumen and releases it at pH 6, in the lumen of endosomes.

TLS Online TPP Program

#Id: 8219

#XL - Q Biochemistry

M6P residues are generated in the cis-Golgi by two Golgi-resident enzymes. 

1. N-acetylglucosamine (GlcNAc) phosphotransferase
2. Phosphodiesterase

TLS Online TPP Program

#Id: 8218

#XL - Q Biochemistry

Sorting signal that directs lysosomal hydrolases from the TGN to the late endosome is- Mannose 6-phosphate (M6P).

TLS Online TPP Program

#Id: 8217

#XL - Q Biochemistry

In selective autophagy

specific cargo is packaged into autophagosomes that tend to contain little cytosol, mediates the degradation of worn out, or unwanted, mitochondria, peroxisomes, ribosomes, and ER; used to destroy invading microbes.

TLS Online TPP Program

#Id: 8216

#XL - Q Biochemistry

In nonselective autophagy, a bulk portion of cytoplasm is sequestered in autophagosomes

TLS Online TPP Program

#Id: 8215

#XL - Q Biochemistry

Autophagy can be either

• Nonselective autophagy

• Selective autophagy