The allelic frequency at equilibrium (qˆ) depends on the relative fitnesses (usually expressed as selection coefficients) of the two homozygotes:

TLS Online TPP Program

#Id: 9978

#XL - T Zoology

β-catenin binds to TCF to displace the Gro repressor and recruits co-activator proteins Pygo, LGS, to activate target gene expression.

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#Id: 9979

#XL - T Zoology

Active Wnt signaling leads to the secretion of Notum.

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#Id: 9980

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Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation.

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#Id: 9981

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Delipidation process reduces Wnt signaling, creates a negative feedback mechanism for preventing excessive Wnt signaling.

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#Id: 9982

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Frizzled receptor possesses a unique hydrophobic cleft adapted to interact with lipidated Wnts, a binding conformation mimicked in Notum’s structure as well.

TLS Online TPP Program

#Id: 9983

#XL - T Zoology